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A novel approach to crystallisation of nanodispersible ...

A novel approach to crystallisation of nanodispersible microparticles by spray drying for ... nanoparticles (Vergote et al., 2001) or to produce amorphous nanoparticles (Chow and …

Preparation of chitosan nanoparticles by spray drying and ...

Apr 01, 2014 The size of particles produced by spray drying depend on the initial feed and on operating conditions. Most reports indicate that the size of chitosan particles produced by spray drying is from 3 to 50 μm, much larger than the size of the nanoparticles in our work [15–17, 19–21].The different particle size in our work compared with previous work is because we …

PLA/PLGA nanoparticles prepared by nano spray drying ...

Apr 16, 2019 Arpagaus C (2011) Nano spray dryer B-90: literature review and applications, [email protected] Information Bulletin, Number 63/2011. Arpagaus C (2012) A novel laboratory-scale spray dryer to produce nanoparticles. Dry Technol 30:1113–1121. CAS Article Google Scholar

Production of amorphous nanoparticles by supersonic spray ...

Aug 28, 2015 Amstad et al. made amorphous nanoparticles from organic and inorganic compounds—even table salt—using droplets of dissolved compounds created with a microfluidic nebulator. The solvent evaporates fast enough that nanoparticles form before crystal nuclei can develop. The small particle size inhibits crystallization for periods of months.

PRODUCTION OF NANOPARTICLES THROUGH A

Bchi Corporation manufactures two spray dryers for lab-scale production of spray dried product called Mini Spray Dryer B-290 and Nano Spray Dryer B-90. While the B-290 is able to generate microparticles, the B-90 claims to produce nanoparticles. The aim of this project was to design a novel nozzle that can aid in production of nanoparticles when

A novel copper-matrix composite with fullerene soot ...

Dec 01, 2021 A novel copper-matrix composite with fullerene soot nanoparticles produced by molecular level mixing. ... The suspension was spray dryed at 150 C using Buchi Spray Dryer B-290. The produced precursor powder was heated up to 400 C in air atmosphere to form copper oxide. ... To produce compact specimens the composite powder was cold pressed ...

Orally Administered Nano-curcumin to Attenuate Morphine ...

Dec 02, 2013 A high inlet temperature of the spray dryer could induce active chain motion and result in permanent agglomeration of the particles, due to the relatively low glass transition temperature of the PLGA. The size of PLGA-curcumin nanoparticles increased from 70 nm to about 165 nm (Figure 1A). Dimers and trimers were formed during the spray drying ...

Biotech Companies in India PDF Fine Chemical ...

Development of novel and sustained NA release formulations; Chemical syntheses and discovery of novel drug candidates for neglected tropical diseases, infectious diseases and Emmellen Pharmaceuticals Ltd, 501, Sentinel, Hiranandani Gardens, Powai, Mumbai, Maharashtra Biotech Maharashtra 400076 91-22-66797200 91-22-66797222 Email. [email protected]

SUPERCRITICAL FLUID TECHNIQUE FOR PARTICLE ... - DeepDyve

Feb 01, 2005 Supercritical Fluid (SCF) technology is now considered as a very innovative and promising way to design particles, especially for therapeutic drug formulation.(l) The advantages of SCF technology include use of mild conditions for pharmaceutical processing (which is advantageous for labile proteins and peptides), use of environmentally benign nontoxic …

Nano and microparticle engineering of water insoluble ...

Feb 01, 2012 Preparation of nanoparticles was carried out by the Nano Spray Dryer B-90 (Bchi, Switzerland). To obtain drug loaded nanoparticles 100 mg of either CyA or DEX and 500 mg of PLGA of different lactide:gylcolide ratio and molecular weights were accurately weighted and dissolved in 0.5–2% solid content of a dichloromethane/ethanol (70/30%, v/v) organic …

Effects of spray drying process parameters on the ...

Generally, the yield% of spray-drying at laboratory scale with conventional spray-dryers is not optimal (20-70%) due to the loss of product in the walls of …

Formulation and characterization of clozapine and ...

In the current study, polylactide-co-glycolide (PLGA) nanoparticles entrapping both clozapine (CLZ) and risperidone (RIS) were formulated by spray-drying using Buchi Nano Spray Dryer B-90 (Flawil, Switzerland). Parameters such as inlet temperature, spray mesh diameter, sample flow rate, spray rate a …

(PDF) Conductive Cellulose based Foam Formed 3D Shapes ...

In this article, we introduce for the first time, a method to manufacture cellulose based electrically conductive non-woven three-dimensional (3D) structures using the foam forming technology. The manufacturing is carried out using a minimum amount

Development of Orally Applicable Combinatorial Drug ...

In this study, orally applicable nano-sized chitosan nanoparticles (NPs) were successfully prepared using Nano Spray Dryer. It is possible to produce these NPs in large quantities by simply increasing the processing time using the machine without changing any parameter. A chemotherapeutic agent (imatinib mesylate; IMA) and nonsteroidal anti ...

Liquids to Powders Without Heat No Heat Spray Drying ...

industries to replace heated spray drying and freeze drying—the two most com-mon techniques in use today. In addition, DriZoom has the potential to atomize and dry some emulsions previously deemed too viscous for spray drying. Novel applications could potentially lead to new products and processes to boost U.S. competitiveness in global markets.

Hydroxypropyl-Beta-Cyclodextrin as ... - SciTechnol

Introduction. Nano-spray drying is a new method to achieve drug particles in nanosize with high yield and low cost. The nano-spray dryer consists of inlet tube for sample entry and outlet one to recovery the excess sample to be used again without causing any loss in sample volume, and it also consists of drying chamber, electrostatic stainless steel collecting cylinder and different …

Dry Powder Formulation of Simvastatin Nanoparticles for ...

It has been hypothesized that simvastatin could be used to treat pulmonary arterial hypertension (PAH). This study is intended to formulate a simvastatin nanoparticle dry powder inhalation (DPI) formulation. Simvastatin nanoparticles were prepared via an emulsification and homogenization-extrusion method, followed by spray drying of the colloidal suspension of simvastatin …

Nano Spray Drying of Pharmaceuticals - SciRes Lit

Jul 12, 2018 Arpagaus CA. Novel laboratory-scale spray dryer to produce nanoparticles. Drying Technology. 2012; 30: 1113-1121. https://goo.gl/6Hv3xp; Arpagaus C. Nano Spray Dryer B-90: Literature review and applications, [email protected] Information Bulletin. Number 63/2011, 2011. https://goo.gl/9Xwom8

Flow nanoprecipitation of size-controlled d-leucine ...

Jul 29, 2019 In this work we report a novel flow-based method for the flash nanoprecipitation of size-controlled D-leucine nanoparticles for spray-drying formulations. Preliminary experiments were conducted in batch to define the best flowable conditions that were then optimized considering the nanoparticle size and distribution using a mesofluidic flow system.

A novel strategy to produce highly stable and transparent ...

Jun 27, 2011 This has great potential to offer a novel solution for innovative drugs of the future. ... Spray-drying was carried out using a laboratory scale spray dryer (SD-Basic, Labplant, UK) under the following ... Figure 4 gives SEM images of the precipitated SLB nanoparticles obtained at 50 C and the water-redispersible SLB nanoparticles of powder ...

E-Book On RD Opportunities in Drying PDF - Scribd

Kudra and Mujumdar (1995) have classified and discussed various novel dryers, ranging from laboratoryscale curiosities (e.g., acoustic drying, drying of RD Needs and Opportunity in Drying 31 slurries by impinging sprays over a hot surface) to pilotscale demonstrations (e.g., pulse combustion dryers, ultrasonic spray dryers, impinging stream ...

Spray drying OZ439 nanoparticles to form stable water ...

Mar 22, 2019 When swapped from water through FaSSGF to FaSSIF, spray dried nanoparticles exhibited dissolution superior to both unencapsulated powder and lyophilized NPs (Fig. 7). Spray dried NPs achieved over 20-fold higher solubilized OZ439 than unencapsulated powder after 6 h and solubilized up to 86% of the OZ439 in the system.

Nanoparticles by spray drying using innovative new ...

Nanoparticles by spray drying using innovative new technology: the Bchi nano spray dryer B-90 J Control Release. 2010 Oct 15;147(2) :304-10. doi ... notably for laboratory scale devices. This study presents the Nano Spray Dryer B-90, a revolutionary new sprayer developed by Bchi, use of which can lower the size of the produced dried ...

Drug Delivery Nanoparticles Formulation and ...

Nanoparticles were formulated using 2% and 5% (w/v) PVA as an emulsifier. VSMCs (50,000 cells per plate in a 24-well plate) were allowed to attach for 24 hours, the medium was changed with a suspension of nanoparticles (100 mg/mL) prepared either in SM or SFM.

Assembly of uniform ... - Wiley Online Library

Nov 04, 2010 Generation of uniform micro-particles containing (i) pure lactose; (ii) silica nanoparticles and lactose; (iii) silica nanoparticles/lactose doped with Eu(III) have been successfully achieved using a novel spray dryer with a uniquely designed microfluidic aerosol nozzle as the monodisperse droplet generator.

Uniform Chitosan Microparticles Prepared by a Novel Spray ...

Nov 04, 2010 These droplets were well dispersed and dried in a microfluidic-jet spray dryer (MFJSD).The drying process was specially designed to ensure identical drying experience for every individual droplet to acquire homogeneous microparticles. In this study, we tackled the issue of preparing uniform microparticles using the novel spray-drying technique.

A Review on Ocular Novel Drug Delivery Systems of ...

Nov 07, 2020 Generally, nanoparticles are solid dispersed particles which can be polymers and of sub-micron size, preferably less than 500 nm. Based on the techniques used to prepare nanoparticles, they can be obtained in the form of nanospheres or nanocapsules. The first medical application of nanoparticles was in 1976 by Peter Speiser.

Novel Spray-Dried Genipin-Crosslinked Casein Nanoparticles ...

Nov 08, 2012 The solid nanoparticles were then obtained by spray-drying of this solution using a Bchi B-290 Mini-Spray Dryer (Flawil, Switzerland), equipped with a high-performance cyclone, a two-component nozzle and current flow, with inlet temperature of 150C, outlet temperature of 90C, aspiration air of 90%, feed flow of 5 mL/min, spraying pressure ...

Effective spray drying technique to prepare nanocomposite ...

Oct 01, 2019 Here, nanocomposite particles comprising microparticles of a sugar alcohol, MAN, containing SMV nanoparticles were prepared using a spray dryer with a two-solution mixing-type nozzle. Four ratios of SMV/MAN (1/3.3, 1/5.5, 1/11.3 and 1/18.6; w/w) were spray dried and the SMV/MAN particles were observed by SEM . SMV/MAN ratios (w/w) of 1/5.5, 1 ...

A novel approach to crystallisation of nanodispersible ...

Oct 15, 2012 SD of CTZ (Sigma, Germany) samples using conditions as outlined in Table 1 was performed using a Bchi B-290 Mini Spray Dryer (Bchi 93001 en).Tablets (n = 10) were compressed using a MTCM 1 tablet press (GlobePharma, USA), supplied with concave 10 mm diameter tooling.Tablets (n = 10) were subjected to hardness test using Dr. Schleuniger-6D …

Nanoparticle Technology for Drug Delivery (Drugs and the ...

Single-Particle Optical Sensing Three different aqueous suspensions of celecoxib nanoparticles of decreasing size (Fig. 2B–D) were produced via a laboratoryscale process as a means of evaluating the effect of particle size on the extent and onset rate of oral drug absorption for this compound (65).

Spray Drying Thesis 2014 Computational Fluid Dynamics ...

Spray dryers with a capacity of 1 t/h typically consume 4-5 times more energy in evaporating a unit mass of moisture ... plasma and many others (Masters, 1985). Recently, spray drying has been used to produce nanoparticles in laboratory scale equipment (Arpagaus, 2012; Khan et …

(PDF) Silica/Lignin Carrier as a Factor Increasing the ...

The article aims to present results of research on anaerobic digestion (AD) of waste wafers (WF-control) and co-substrate system–waste wafers and cheese (WFC-control), combined with digested sewage sludge, as inoculum. The purpose of this paper is to

Energies Free Full-Text Silica/Lignin Carrier as a ...

The article aims to present results of research on anaerobic digestion (AD) of waste wafers (WF-control) and co-substrate system–waste wafers and cheese (WFC-control), combined with digested sewage sludge, as inoculum. The purpose of this paper is to confirm the outcome of adding silica/lignin (S/L; 4:1) material, as a microbial carrier, on the process performance and …

[PDF] Nanocapsules formation by nano spray drying ...

The nano spray dryer B-90. The Buchi Nano Spray Dryer B-90 offers a new, simple and alternative approach for the production of nanoparticles suited for a variety of drug delivery applications and has to contend with the issue of adequate redispersibility of the primary particles to reap the full benefits of nanosizing.

Advances in Spray Drying Technology for Nanoparticle ...

The widespread research investigation of nanoparticles as a mode of drug delivery has translated to the late development of spray drying technique with advancement focuses on atomization mechanism to produce discrete dried nanoparticles. This chapter describes spray drying processes and processors for particle production from micro- to ...

Pharmaceutical nanoparticle isolation using CO 2-assisted ...

The work presented herein demonstrates a novel production and isolation method for drug nanoparticles using a 'top spray dynamic bed coating' process, which uses CO 2 spray as the fluidizing gas. Nanoparticles of three BCS class II Active Pharmaceutical Ingredients (APIs), namely carbamazepine (CBZ), ketoprofen (KET) and risperidone (RIS), were ...

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