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Infrared microscopy for in situ measurement of protein ...

A commercially available freeze-dry microscopy stage interfaced with an IR microscope is described as a method of in situ measurement of protein secondary structure in the liquid, frozen and freeze-dried states. Studies using solutions of model proteins demonstrated that spectra collected using the IR microscope have resolution and sensitivity ...

Replacement Parts for EMS 750 Freeze Dryer Electron ...

A freeze dryer or lyophylizer freezes material and then reduces the pressure and adds heat so that the frozen water is sublimated. Using manifold, batch, or bulk methods, freeze dryers dehydrate materials for optimum preservation and recovery. Incorporating a vacuum system, the machines extract water molecules by creating a lower pressure that will attract the molecules …

Freeze Dryer Microscope -

A simple freeze-dryer and the cytological examination of ... A simple freeze-dryer and the cytological examination of frozen-dried tissue with the use of vital dyes and the Baker interference microscope J R Microsc Soc . 1955 Aug;75(1):48-57. doi: 10.1111/j.1365-2818.1955.tb00407.x.

Accurate prediction of collapse temperature using optical ...

A single-vial freeze dryer coupled with optical coherence tomography freeze-drying microscopy (OCT-FDM) was developed to investigate the structure and Tc of formulations in pharmaceutically relevant products containers (i.e., freeze-drying in vials). OCT-FDM was used to measure the Tc and eutectic melt of three formulations in freeze-drying vials.

New freeze drying microscope offers clearer images for ...

Apr 10, 2014 Freeze drying microscopy is an established technique for accurately and easily establishing the point of collapse, the most important critical temperature for developing safe and robust freeze drying cycles. Essentially operating as a micro freeze-dryer, FDM enables freezing and drying of a real sample to be observed in real time. As FDM ...

Freeze drying microscope provides clearer images for ...

Apr 11, 2014 Freeze drying microscopy (FDM) is an established technique for establishing the point of collapse, the most important critical temperature for developing safe and robust freeze drying cycles. Essentially operating as a micro freeze-dryer, FDM enables freezing and drying of a real sample to be observed in real time.

Cycle Development in a Mini-Freeze Dryer: Evaluation of ...

Apr 26, 2021 Product resistance profiles showed uniformity in all of the runs conducted in the mini-freeze dryer, but absolute values were slightly lower compared to values determined by MTM in a LyoStar™ pilot-scale freeze dryer. ... (−33C) was determined in advance by light transmission freeze dry microscopy and used as input parameter for the SMART ...

Freeze Dryers - Laboratory Supplies Equipment

Contact. Get all the help you need from one of our experienced customer service representatives. 800.621.7193; [email protected]

Optical coherence tomography-based freeze-drying microscopy.

Dec 07, 2011 A new type of freeze-drying microscope based upon time-domain optical coherence tomography is presented here (OCT-FDM). The microscope allows for real-time, in situ 3D imaging of pharmaceutical formulations in vials relevant for manufacturing processes with a lateral resolution of 7 μm and an axial resolution of 5 μm. Correlation of volumetric …

Freeze Dryer - Bioevopeak

Fluorescence Microscope (2) Inverted Microscope (2) Metallurgical Microscope (3) Stereoscopic Microscope (6) Polarizing Microscope (4) Digital Microscope (3) Biological Microscope (17) Teaching Microscope (5) Freeze Dryer (8) Liquid Nitrogen Tank (9) Microplate Washer Reader (8) Microplate Washer (2) Microplate Reader (6) Air Generator ...

GMP Freeze Dryers - Telstar

GMP Freeze Dryers. Improvements in the process of Freeze drying and of the equipment to carry it out have been a continuous challenge since Telstar’s very beginnings. The design of units for efficient drying under as aseptic conditions as possible has led to the development of specific equipment solutions for use in laboratory and industrial ...

Bench Top Freeze Dryers - with Omnitronics/Intellitronics ...

Here is an overview of our laboratory freeze-dryer, which handles product capacities from 2.5 kg to 24 kg per drying cycle. The version with LSCbasic control is particularly suited to standard applications in round-bottomed or similar flasks and small quantities in …

PAT for freeze drying: cycle optimisation in the ...

Jan 25, 2007 Collapse temperatures can be determined by freeze-dry microscopy (FDM), a technology where the product drying behaviour can be observed in a custom made freezing stage through a microscope 5,6. A common standard to determine Tg’ or Teut is differential scanning calorimetry (DSC) 3,4.

Freeze dryer Labmate Scientific Ltd

Labmate Freeze dryers. Mail : [email protected] Phone : +44 797 948 5982 Address : 82A James Carter Road , Mildenhall Industrial Estate , Suffolk IP28 7DE , United Kingdom.

Freeze-Dry Microscopy: Impact of Nucleation Temperature ...

May 14, 2009 The objective of this study was to investigate the impact of nucleation temperature (T n) and excipient concentration on the collapse temperature data obtained from freeze-dry microscopy (FDM) experiments. T n, the temperature of the onset of collapse (T oc), and the full collapse temperature (T fc) were determined for aqueous solutions of polyvinylpyrrolidone …

Freeze Drying Medicago

Medicago has several freeze dryers in the scale up to 3500 vials or 30 kg liquid that we use to run pilot scale or small production batches in. These freeze dryers are available in various purity zones and we can therefore meet the purity requirements of those most in demand. ... Using a freeze-drying microscope makes it possible to develop ...

China Freeze Dryer Laboratory Manufacturers - Freeze Dryer ...

NBJ-10 Gland Vacuum Freeze Dryer. Brand:NANBEI Model:NBJ-10 Application:Laboratory, We're known as one of the most professional freeze dryer manufacturers in China, providing high quality laboratory equipment. Please be free to buy freeze dryer at competitive price from our factory. mini spray dryer, industrial spray dryer, glass pressure reactor.

A freeze-drying microscopy study of the kinetics of ...

Nov 23, 2017 Freeze drying microscopy has been used to probe the lyophilisation kinetics of lactose solutions of various concentrations, at temperatures ranging from −50 C to −30 C and under a constant pressure of 1 Pa. Sublimation front velocities were determined by recording a sequence of video images of the sublimation and analysing the frontal progression using …

Fundamentals of Freeze Drying - Pharmahub

Oct 23, 2018 Characterization of Freeze Drying Behavior –Freeze Dry Microscopy. Sources of Uncertainty in FD Microscopy •It is often not clear what level of collapse, as observed by ... •Any freeze dryer has a limit as to the sublimation rate that it will support. In order to optimize the process, we need to

Freeze Dryer Automatic LYO40/LYO70 - Bioevopeak

Operate on touch screen, one key start and automatic control freeze-drying process, easy and convenient operation. 6. Set and real-timely adjust freeze -drying technology by requirement and show the freeze-drying data and curve. 7. Advanced system, small running current and low energy consumption. 8.

[PDF] Freeze drying microscopy as a tool to study ...

Published 2015. Materials Science. Freeze-drying is the process of removal of water or organic solvent from a desired product by means of sublimation at a low temperature and low pressure. It is commonly employed for drying samples which are heat labile and require sensitive treatment, and is mainly used in the pharmaceutical and food industries.

Freeze-Dry Microscopy of Protein/Sugar Mixtures: Drying ...

Sep 01, 2009 Freeze-Dry Microscopy (FDM): Technical Setup. The freeze-dry microscope system consisted of a Zeiss Axio Imager.A1 microscope (Carl Zeiss MicroImaging, Gottingen, Germany) with a lambda plate plus spectrum analyzer and a FDCS 196 freeze-drying stage (Linkam Scientific Instruments, Surrey, UK) with a liquid nitrogen cooling system and a …

Freeze-Dry Microscopy of Protein/Sugar Mixtures: Drying ...

Sep 01, 2009 The freeze-dry microscope system consisted of a Zeiss Axio Imager.A1 microscope (Carl Zeiss MicroImaging, Gottingen, Germany) with a lambda plate plus spectrum analyzer and a FDCS 196 freeze-drying stage (Linkam Scientific Instruments, Surrey, UK) with a liquid nitrogen cooling system and a programmable temperature controller. ...

Smart Freeze Dryer Technology : A Review PharmaTutor

Sep 12, 2020 Freeze dry microscopy (FDM) is the best method to obtain this value. Differential scanning calorimetry (DSC) is also used. 6. Concentration of Solution: The amount of solute per unit amount of solution (g/g). 7. MTM Interval (minutes): This value will determine how often the isolation valve is closed during primary drying to perform the ...

Freeze Dryer Uytengsu Teaching Lab

Spectroscopy, Chromatography Microscopy Main content start. Freeze Dryer, FreeZone6 Function: Freeze-drying—technically known as lyophilisation, lyophilization, or cryodesiccation. The dehydration process works by freezing the material and then reducing the surrounding pressure to allow the frozen water in the material to sublimate directly ...

Freeze-Dry Microscopy of Protein/Sugar Mixtures: Drying ...

The collapse temperature of the sucrose solution (−33C) was determined in advance by light transmission freeze dry microscopy and used as input …

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